drilling acrylic

[Snappy]

I know this should probably go in the DIY forum but it seems that there aren't as many responses through there.
Anyway I need to drill an existing acryic tank and am wondering if there are tips or tricks I should be aware of. I plan to use a hole saw and run 1.5" pvc for a stand pipe that runs to the sump of my main display so I can increase water volume and act as a refugium.
Any suggestions?