In my personal experience Cyano if introduced to the tank on a coral or piece of rock can thrive in a well balanced and mature reef tank. Yes yes I know algae needs light and nutrients but I have seen several cases where the stuff needs to be eradicated in order to get rid of it and then said tanks are fine afterwards. So I have used Chemi clean and find it works very well. If your nitrates are low/undetectable and you have good flow new bulbs and are not overfeeding I would recommend it and given the above it should not come back. Be careful to follow the directions though I always add an air pump line for oxygenation turn the skimmer off (if you decide to turn it on!) and follow the directions on the water change.
On the skimmer note I must admit I dont have a lot of faith in skimming. I dont disagree that it has a purpose and becuase it is used in industrial applications that to me gives more creedence to it. But the articles I have read on the amount of organics removed by typical aquarium skimmers makes me doubt their overall utility as a must have. With that said I have a couple and use them just like everyone else I think they are a component to a healthy reef tank but not the be all end all in my opinion (thats why I will never own a Bubble King lol....)
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