Yup just follow the directions good and shouldn't have any problems
I leave my skimmer running and just leave the plug undone sour flows back into the sump so you get lots of airation during the treatment
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Current tank---125 gallon mixed reef 60 gallon sump, Reef octopus nw200 skimmer, Rapid LEDs, Maxspec gyre, Mp10s, Fuge, Biweekly 20% WC, QT everything
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