Many of the organisms we're so worried about shocking you can't see.
In a pico, you really have no choice but to do large waterchanges.
I would bet your biofilter sucks in that thing as you are constantly setting it's establishment back every time you "shock" it.
You may have never personally seen any negative effects, but you would if for example you had the exact same tank set up and just did 20% water changes weekly to compare it too.
The article on large water changes likely has accomplished aquarists who do test and calibrate their water before doing a large water change.
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