maybe one fish died and caused ammonia, and that can burn the remaining fish or create a lack of oxygen. 16 fish in 150 gallons is a lot, unless they are all small fish. It's 5 gallons of water per 1'' of fish, so that's 30'' of fish, devided by 16, all your fish would need to be like 1.8'' and I am guessing they are much larger then this....
Just overstocked I guess. I don't know the size of your sump but that still make it a lot of fish. Even in 200 gallons your fish would need to be 2.5'' each.
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More fish die from human stupidity than any other disease...
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