Yes it is possible.
I upgraded the Rio 1400 on my remora pro to a mag 5. You have to make sure the connection is tight or it will blow it off and shoot water all over the walls.
Also if you are using an Aqua-C preskimmer box you may have to thin the foam pad on the return side to increase the flow or it will back up and overflow.
Not that any of this has ever happened to me...
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