The only problem I see with a too large bioload is if the skimmer fail, then oxygen goes down and the fish start to die from lack of oxygen. The rule for the number of fish per gallon is not only for the fish comfort, but it is also for the amount of dissolve oxygen so that all fish can have enough. Using a skimmer really change those odds, but remove the skimmer for a few hours or overnight and disaster can strike.
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More fish die from human stupidity than any other disease...
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