Cuba is nice, but I haven't been with kids so can't suggest family activities. I don't see any problem with your wife going. If you go, make sure you book 5 star, as that's going to be about a 3 star anywhere else. If you go to a resort, eat local food, it's what they make best. There are a lot of good restaurants in town, and you can probably arrange a home cooked meal through someone at the hotel. Some of the best meals I had was while staying with a family in Havana.
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Brad
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