Every time I have used hypo, I was 100 % successful. I did have some live rock, and the bristle worms died, but that's all I noticed. I didn't have much for pods in my QT. With all the water changes to get the salinity down, and a mature canister filter, I didn't have any water quality issues.
Of course this was in 30g QT, so can't say what will happen in a large DT full of live rock.
As has been already stated here, and I will say it again very emphatically, be sure to get it down to 1.008 or 9. Use a calibrated refractometer. And keep it there for at least 6 weeks.
If you do this, please let us know how it works. I have never heard of anyone going hypo with a large DT.
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