Have at 'er if you want to Hypo your rock
I did a small piece in the QT and it killed aiptasia
Plus all the big worms came out for capture, and it killed ugly palys, tube worms, feather dusters and the like
Just keep in mind that all the die-off in it will add to any potential ammonia issues, and slow down your DT's recovery after you re-introduce the fishies
Up to you, but I wouldn't hypo my rock
It's like starting over, but without any bacterial filtration