I've had 2 cowfish die on me, one in my first tank (a 45g), I was doing a water change and cleaning the sand and nicked him with the syphon (they are super curious and he was always right where I was in the tank). I didnt know about the toxin, and all of my fish died. I tried another one a little while ago with a porcupine puffer. The puffer got ich and spread it to the cowfish. I got up in the middle of the night one night and found the cowfish stuck hornfirst in the powerhead. I pulled him out and he swam around a bit, but he didnt look so good so I removed him from the tank to quarantine him. He ended up dying, but I wasn't sure if I had removed him from the tank in time, so I ran carbon and did a water change. Everything in the tank was fine. I think they are awesome fish if you can keep them from getting stressed. They have tons of personalilty, just keep carbon ready if you do plan on keeping one, just in case.
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