I use to run 2 skimmers, but had issues. I found that I had to have 2 skimmers of equal capabilities. For example I ran a EuroReef RS180 and a Tunze DOC skimmer, but the Tunze never worked, and never pulled an ounce of skimmate, but when I bought the Hydor, and ran it with the EuroReef, I had much more success. Eventually I sold the Euro, and ran the Hydor and SWC 160 without issue.
But in stating the above, I would have to now agree with Mike and say, it is easier to run a skimmer than can handle the highest bioload possible for your tank size. It takes up less room, uses less power and is overall just easier.
Just my 2 cents, and I can now say I only run the one skimmer.
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Setup: 180G DT, 105G Refuge (approx. 300lbs LR, 150lbs Aragonite)
Hardware: Super Reef Octopus SSS-3000, Tunze ATO, Mag 18 return, 2x MP40W, 2X Koralia 4's Wavemaker
Lighting: 5ft Hamilton Belize Sun (2x250W MH, 2X80W T5HO)
Type of Aquarium: mixed reef (SPS & LPS) with fish
Dosing: Mg, Ca, Alk
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