From my experience they are hit and miss when it comes to hardiness and it is more often a miss. The biggest problem is getting them to eat. If you can do that then generally they do well, but some just refuse to eat no matter what you do.
With that being said, I do have one currently in a softie/lps tank. For the most part he seems to leave everything alone but is really hard on the big fleshy brains. Other than that, he has left the zoanthids, leathers, euphyllia, etc alone. I don't have any clams in there however.
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32"x32"x20" Cube-ish tank
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