This depends on yoru current nutrient load
PO4
NO3
also you need to make sure your mineral levels are correct
DKH - 7-8
MG - 1280 -1350
Ca - 380 - 430
But my concern is you said you had lost a lot of sps, if this was due to a pathogen then Prodi will not stop the same pathogen coming back for a second course.
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