You could try making an obstacle/divider system that has holes only big enough for the smaller one to get through. Lots of times I have had fish with aggression issues that settled down over time. It is possible that they could become compatible with each other, as long as the smaller one has a safe place of refuge.
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120 gallon sps/anemones/LPS reef since 2004
Apex controller
8 x 54 watt T5 PowerModule
Herbie's silent overflow system
Jebao DC 12000 return pump
Jecod CP-40 Cross-flow circulation device
Mini Bubble King 180
Barr Aquatics calcium reactor
Bucket fuge
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