It realy depends on your entire setup. Is your frag tank beside your main tank, sharing a sump? That would dictate which side. My current tank is centred, and that works best to enter one side of my off centre sump. Really, it has no effect where you put it, other than where the plumbing will go down. You may need a couple of extra 90s if it's got to traverse the stand to get to the out flow area.
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Brad
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