I have done it several times to my display, and have never had a major issue. So long as you dont stirr the sand bed up too much to the point where you cant see in the tank anymore, and dont leave the rock out for 8 hours.
I always end up re aquascaping, then as soon as all is done, do a H20 change, and have never noticed anything different. Although, im sure that there is always the possiblity.
