Also note health wise: Eye concerns since many have excessive drooping to the lids, possible nasal issues dues to smushed face, prone to allergies, and many cancers. Just to mention a few more to consider. However there are few large breeds that do not have a "list" to watch out for!

Yes aggression can be curbed with HUGE socialization! ESP while she's young.
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45 Gallon Cube with 10 Gallon Sump, Lighting 8 bulb T5, Vertex IN 80 Skimmer
-2 Occelaris Clowns, Engineer Goby, RBTA, Peppermint Shrimp