Be wary of overreacting. I'm very sorry about the angels but treating a main tank is a recipe for disaster. I don't mean to sound cruel here, but listen to yourself: is a medication intended to kill off flukes reef-safe? By very definition, it is not. The whole idea of a medication is you're trying to poison your tank to the point that the "baddies" drop off while hopefully leaving enough "goodies" leftover to repopulate.
My suggestion is that if you do not 100% unequivocally know for certain that you have flukes in your system, that you do not nuke your tank with any medication.
On the flip side, if you have enough evidence to suggest that other fish may be affected, the wiser course of action is still to catch those fish and treat them separately in a hospital tank. Running your main display fallow of hosts will go far further than any medication.
Be very careful about overreactions in this hobby, it's very easy to overcompensate or overcorrect and then you're facing a worse situation and one of your own making. Please be careful.
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-- Tony
My next hobby will be flooding my basement while repeatedly banging my head against a brick wall and tearing up $100 bills. Whee!
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