It doesn't matter how much fluid you have in there, as long as the "air pocket" is next to the plunger and not somewhere in the middle. I just pull the plunger back to 1ml and run the sample. At the end of the titration it doesn't matter how much solution #3 you have left its about how much you've used.
You could always suck up solution #3 with the yellow tip off and then put it on, shove some liquid through it to get rid of the air and then reload the syringe to the 1ml mark. Works for me
