Depending on the breed it may be time to say goodbye, and put her down. I know it is a hard decision to do, but you may have to do what is best for the dog.
I think at 12 I would stay away from chemo, and go the steroid route to see how she responds, and give you both (you & the dog) some time together.
I ahve had several pets over the years, and have had to say good bye several times, and it is always difficult.
All I can really say it is your decision on what to do, and you just ahve to do what is best for yourself and the dog.
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