I have done 50% water changes every 2 days for a week on my old 75g tank with no stress what so ever. In fact because i was fixing major water quality issues at the time, I only saw a huge improvement with every water change
All of this just proves my skimmer on the 175g sucks
. I took it offline for 2 weeks and all it did was increase my fretfullness, no nitrates, no extra glass cleaning, nothing.