In my opinion and experience, Interceptor is relatively safe and easy to use. You can go out of your way and pull out the colonies and treat them seperatly but..but to me this seems less effective because red bugs can still be alive on your substrate or floating in your water column wich can then lead to reinfestation.
I have ~100 net gal of water and I treated the tank with 1 crushed pill...and only did an 8% water change. I lost maybe couple of snails..but everything else survived and my acros were healthy again.
If you decide to treat your tank..make sure you buy extra pills for Acro quarintine dips for future use. Before I introduce a frag, I always take a salifert size amount of interceptor and treat the frag in a Super Big Gulp container for 3hrs prior to introducing into my display..always do this because red bugs is really rampant in this hobby.
I hope this helps.
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