I have one running on my 33 gallon, I have a moderatly low bioload and feed sparingly - I would be very surprised if mine filled up even half of the collection cup in a week. But fresh is right, it will not overflow. The only problem I have heard with these skimmers (besides the microbubbles and noise) is having the powerhead come detached and pushing water over the edge of the tank, but a zip tie should alleviate any concern of this happening.
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