The only downfall I've heard is that sand has a tendancy to blow around easily when it's new if there's a lot of flow in the tank because it hasn't had a chance to clump with the bacteria yet. Make sure your rinse the new sand first too or else you'll end up with a lot of film in the water when you add it. I hear this method helps keep a tank really healthy though. If sand beds are in fact huge nutrient sponges then this is a great method of removing nutrients.
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Jason
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