The sand bed can become a "problem" in that detrius can build up in/on it, and make it more difficult to control nitrates, algae growth, etc. In my 180 display tank this is not a problem because I have lots and lots of sandsifters and really high flow, so all my detrius that settles gets kicked back up into the water column, then into my filter floss in my sump then out of my tank. In my nano this might be more difficult because it wont be enough sand to keep a dragon goby or some other sand sifters healthy, but maybe there are some smaller gobies that can do the job for me, then I wont have to replace the sandbed, if I keep my flow high and use mechanical filtration.
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