Probably Ick.
If you have sufficient aeration, I'd go with B.
If you medicate him in a Q. Tank, chances are that you already have Ick in your tank so when you put him back in the main tank, he'll get it again anyways.
If you quarantine everything and clean out your main tank, not only is it a lot of work, chances are good that he'll pick up Ick again whenever you get new livestock.
My blue tang has had ick on and off for 2 years even though I have cleaner shrimps and neon gobies. The ick is hardly a problem as the tang has grown fast, is fat, and has solid blue coloration. He's actually outgrown my tank now and I'll be looking to move/sell/trade him soon.
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