Hi Mark! I've found Prodibio to be a great product. I have only used the BioDigest and Bioptim though as I've never a need to use the supplement products. I've also found that the effects seem to wane after using it for awhile, and get better results dosing in spurts. For example, dose once every 2 weeks (as manufacturer suggests) for 5 or 6 doses (10 or 12 weeks), then take a 4-6 week break, then dose again. That's just what I've noticed on my two reefs, as with anything else reef you may find different results. :p